Whisk buttermilk and Louisiana hot sauce in a large bowl. Submerge chicken pieces fully, cover, and refrigerate for at least 4 hours or overnight.
Take the chicken out of the fridge and let it sit at room temperature for 20 minutes. Meanwhile, heat oil in a deep pot or fryer to 350°F (175°C).
In a separate bowl, mix flour, smoked paprika, garlic powder, onion powder, cayenne, white pepper, black pepper, and salt until well combined.
Remove chicken from the marinade and let the excess drip off. Dredge each piece in the seasoned flour, pressing to coat. Shake off any extra flour and set aside.
Carefully lower chicken into the hot oil, a few pieces at a time. Fry for 12–15 minutes, or until golden brown and the internal temperature reaches 165°F (74°C).
Transfer chicken to a wire rack to drain. Let it rest for 10 minutes before serving for juicier, more flavorful meat.