Heat a pan on medium. Add ground beef, salt, pepper, garlic powder, and onion powder. Cook for 6–8 minutes, breaking it up, until no longer pink. Drain the fat.
In a bowl, mix cooked macaroni, shredded cheddar, bacon bits, ketchup, mustard, and the beef. Stir until combined and cheesy.
Place tortillas flat. Add ½ to ¾ cup of filling in the center. Roll them up tightly like burritos.
Brush rolls with melted butter. Heat the pan again. Cook rolls seam-side down for 2–3 minutes per side until golden and crispy.
Cut rolls in half and serve warm with ranch, ketchup, or spicy mayo.