Preheat oven to 200°C (400°F). Line a baking sheet with parchment and lightly grease it.
Soak chicken tenders in buttermilk for at least 30 minutes or overnight in the fridge.
Mix panko, Parmesan, ranch seasoning, garlic powder, onion powder, paprika, salt, and pepper in a bowl.
Beat the eggs in a bowl. Place next to the breadcrumb mixture for easy coating.
Dip each tender in egg, then coat with breadcrumbs, pressing gently to stick.
Place tenders on the baking sheet. Lightly spray tops with cooking spray.
Bake for 20–25 minutes, flipping halfway. Tenders should be golden and reach 165°F (74°C).
Let rest briefly, then serve warm with your favorite dipping sauce.