Preheat oven to 425°F (220°C). Line or grease a baking sheet.
Cut squash into ¼-inch rounds. Pat dry with paper towels.
Mix flour, salt, pepper, garlic powder, and onion powder in one bowl. Beat eggs in another.
Combine breadcrumbs and Parmesan in a third.
Dredge slices in flour, dip in egg, then press into breadcrumbs. Shake off excess.
Place on baking sheet in a single layer. Spray or brush with olive oil.
Bake 15 minutes, flip, spray again, and bake 10–12 more minutes until crispy.
Let cool slightly and serve warm with your favorite dip.