Boil salted water and cook fettuccine until al dente (10–12 minutes). Reserve ½ cup pasta water, then drain and set aside.
Slice chicken into ½-inch thick pieces. Mix panko, Parmesan, garlic powder, Italian seasoning, salt, and pepper in one bowl; beat eggs in another. Dip chicken in egg, then coat in breadcrumb mix.
Heat 2 Tbsp olive oil in a skillet over medium. Cook chicken 3–4 minutes per side until golden and cooked through. Transfer to paper towels.
Melt butter in the same skillet, sauté garlic for 1 minute, then add cream and simmer 3–5 minutes. Whisk in Parmesan until smooth. Season with salt and pepper. Add pasta water if too thick.
Add fettuccine to the sauce. Toss over low heat until fully coated and heated through.
Plate pasta and top with crispy chicken. Garnish with parsley, extra Parmesan, or red pepper flakes. Serve hot.