Preheat the oven to 400°F and line a baking sheet with parchment paper.
Gently mix ground beef, egg, breadcrumbs, onion, garlic powder, salt, pepper, and Worcestershire sauce until just combined.
Roll into 1 inch meatballs, place on the baking sheet, and bake for 15 to 18 minutes until lightly browned and cooked through.
Simmer blueberry preserves, bourbon, ketchup, soy sauce, apple cider vinegar, smoked paprika, and red pepper flakes for 5 to 7 minutes until glossy.
Add baked meatballs to the sauce and simmer for 5 minutes, gently tossing to coat.
Transfer to a platter, spoon extra sauce on top, garnish if desired, and serve warm.