Preheat the oven to 375°F (190°C) and grease a 9×13-inch baking dish.
In a medium bowl, mix together the Caesar dressing, sour cream, Parmesan cheese, garlic powder, onion powder, black pepper, and salt.
Place the chicken breasts in the prepared baking dish.
Spread the Caesar dressing mixture evenly over the chicken breasts, ensuring they are well coated.
Bake in the preheated oven for 25-30 minutes, or until the chicken is cooked through and reaches an internal temperature of 165°F (74°C).
Garnish with chopped fresh parsley (optional) and serve hot.